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Ion transitions and the main operating parameters for lenvatinib, M1, regorafenib (IS) and specific CYP isoform probes of the mass spectrometer.

Journal: Frontiers in Pharmacology

Article Title: Effects of three flavonoids on the metabolism of lenvatinib

doi: 10.3389/fphar.2024.1438259

Figure Lengend Snippet: Ion transitions and the main operating parameters for lenvatinib, M1, regorafenib (IS) and specific CYP isoform probes of the mass spectrometer.

Article Snippet: Lenvatinib, O -desmethyl lenvatinib (M1), internal standard (IS, regorafenib), melatonin, 6-hydroxy melatonin, bupropion, hydroxy bupropion, midazolam and 1′-hydroxy midazolam were purchased from Beijing Sunflower Technology Development Co., Ltd (Beijing, China).

Techniques: